TABLE 4

Effects of placebo and trientine treatment on changes in balance and in urinary and fecal excretion of Cu, Fe, Zn, and Ca between pretreatment (days 1–6) and treatment (7–12) periods in control and diabetic subjects

Control
Diabetic
Mean (95% CI)PMean (95% CI)P
Cu (μmol/6 days)
    Placebo
        ΔBalance−35.8 (−60.7 to −10.9)15.2 (−18.4 to 48.8)
        ΔUrinary excretion0.1 (−0.2 to 0.3)0.2 (−0.4 to 0.7)
        ΔFecal excretion36.3 (12.2–60.3)−15.0 (−44.6 to 14.6)
    Trientine
        ΔBalance1.47 (−33.5 to 36.5)0.065−43.3 (−83.1 to −3.5)0.021
        ΔUrinary excretion23.0 (17.4–28.7)<0.000133.1 (22.2–43.9)<0.0001
        ΔFecal excretion−28.5 (−66.0 to 8.9)0.00418.9 (−26.3 to 44.1)NS
Fe (μmol/6 days)
    Placebo
        ΔBalance−227 (−566 to 113)−50.6 (−330 to 229)
        ΔUrinary excretion−0.02 (−0.51 to 0.47)−0.33 (−0.67 to 0.01)
        ΔFecal excretion235 (−94.3 to 563.8)51.9 (−206 to 310)
    Trientine
        ΔBalance257 (−79.8 to 593)0.034173 (−252 to 598)NS
        ΔUrinary excretion−0.11 (−0.49 to 0.26)NS0.40 (−0.31 to 1.12)0.051
        ΔFecal excretion−306 (−671 to 58.4)0.023−187 (−641 to 266)NS
Zn (μmol/6 days)
    Placebo
        ΔBalance−202 (−344 to −59.7)100 (−108 to 308)
        ΔUrinary excretion4.5 (−1.3 to 10.4)6.6 (−10.5 to 23.8)
        ΔFecal excretion202 (67.7–336)−107 (−306 to 92.2)
    Trientine
        ΔBalance412 (177–648)<0.000198.9 (−137 to 335)NS
        ΔUrinary excretion121 (81.5–161)<0.0001190.4 (124–256)<0.0001
        ΔFecal excretion−562 (−820 to −304)0.0001−302 (−539 to −63.7)NS
Ca (mmol/6 days)
    Placebo
        ΔBalance−27.2 (−47.9 to −6.4)−2.7 (−24.1 to 18.7)
        ΔUrinary excretion−2.6 (−4.7 to −0.57)−2.7 (−6.3 to 0.85)
        ΔFecal excretion30.5 (11.9–49.1)5.7 (−14.0 to 25.4)
    Trientine
        ΔBalance35.2 (4.8–65.6)0.00129.5 (−19.0 to 38.0)NS
        ΔUrinary excretion−2.3 (−5.6 to 1.1)NS−4.7 (−8.3 to −1.1)NS
        ΔFecal excretion−37.4 (−69.7 to −5.1)0.00065−6.2 (−37.0 to 24.5)NS
  • Data are means (95% CI); n as in Table 3. Determined with one-way ANOVA. Exact P values are given for trientine treatment vs. corresponding placebo treatment.