TABLE 1

Baseline characteristics by treatment group

OverallPlaceboMetforminLifestyle
n3,2341,0821,0731,079
Age (years)50.6 ± 10.750.3 ± 10.450.9 ± 10.350.6 ± 11.3
Sex
    No. males (%)1,043 (32.3)335 (31.0)363 (33.8)345 (32.0)
    No. females (%)2,191 (67.7)747 (69.0)710 (66.2)734 (68.0)
Weight (kg)94.2 ± 20.394.3 ± 20.294.3 ± 19.994.1 ± 20.8
BMI (kg/m2)34.0 ± 6.734.2 ± 6.733.9 ± 6.633.9 ± 6.8
Waist (cm)105.1 ± 14.5105.2 ± 14.3104.9 ± 14.4105.1 ± 14.8
Waist-to-hip ratio0.92 ± 0.090.92 ± 0.080.93 ± 0.090.93 ± 0.09
Physical activity (MET h/week)16.3 ± 25.817.0 ± 29.016.4 ± 25.915.5 ± 22.1
Fasting glucose (mg/dl)106.5 ± 8.3106.7 ± 8.4106.5 ± 8.5106.3 ± 8.1
HbA1c (%)5.9 ± 0.55.9 ± 0.55.9 ± 0.55.9 ± 0.5
HOMA-IR
    Mean7.1 ± 4.27.1 ± 4.27.2 ± 4.17.0 ± 4.3
    Median6.26.26.26.0
Fasting insulin (μU/ml)
    Mean26.7 ± 15.226.7 ± 15.027.0 ± 14.926.5 ± 15.5
    Median24.024.024.023.0
Fibrinogen (mg/dl)383.8 ± 85.4386.4 ± 85.7379.7 ± 84.7385.2 ± 85.6
    Men356.46 ± 77.83357.34 ± 80.96353.00 ± 80.12359.26 ± 72.15
    Women396.75 ± 85.74399.37 ± 84.59393.40 ± 83.76397.33 ± 88.74
CRP (mg/l)5.90 ± 7.386.06 ± 7.665.82 ± 7.975.83 ± 6.44
    Men3.22 ± 5.323.07 ± 3.593.28 ± 7.113.31 ± 4.47
    Women7.18 ± 7.877.40 ± 8.577.11 ± 8.077.01 ± 6.87
Median CRP (mg/l)3.73.83.53.8
    Men1.92.01.82.0
    Women4.95.14.75.0
  • Data are means ±SD unless otherwise indicated.