TABLE 1

Metabolic parameters during basal and hyperinsulinemic-euglycemic clamp periods in the wild-type and FOXC2 Tg mice fed normal diet or high-fat diet for 3 weeks

nBody weight (g)Basal period
Clamp period
Plasma glucose (mmol/l)Plasma insulin (pmol/l)Plasma glucose (mmol/l)Plasma insulin (pmol/l)
Wild-type826 ± 17.2 ± 0.476 ± 56.1 ± 0.5339 ± 75
FOXC2 Tg827 ± 17.0 ± 0.460 ± 46.0 ± 0.4399 ± 75
Wild-type high-fat fed832 ± 18.6 ± 0.9124 ± 10*6.3 ± 0.9357 ± 53
FOXC2 Tg high-fat fed832 ± 17.1 ± 0.482 ± 105.8 ± 0.5272 ± 38
  • Data are means ± SE.

  • *

    * P < 0.05 vs. wild-type mice by Duncan multiple range test.