General parameters of STZ-induced diabetes in wild-type and MT-TG mice
| Groups | WBGL (mmol/l) | BWG (g) | HWR (%) | KWR (%) | HbA1c (%) | Serum TBARS (nmol/ml) |
|---|---|---|---|---|---|---|
| Wild type | ||||||
| Control | 4.2 ± 0.3 | 1.28 ± 0.36 | 0.45 ± 0.02 | 0.75 ± 0.04 | 2.10 ± 0.04 | 11.0 ± 0.3 |
| Diabetes | 15.0 ± 0.3* | −0.61 ± 0.65 | 0.46 ± 0.05 | 0.92 ± 0.05* | 3.07 ± 0.15* | 16.6 ± 0.8* |
| Diabetes/insulin | 7.6 ± 1.1† | 1.25 ± 0.50 | 0.45 ± 0.10 | 0.77 ± 0.45 | 2.21 ± 0.56 | 12.5 ± 1.3 |
| MT-TG | ||||||
| Control | 4.1 ± 0.2 | 1.17 ± 0.28 | 0.44 ± 0.01 | 0.76 ± 0.03 | 2.09 ± 0.12 | 12.4 ± 1.0 |
| Diabetes | 14.9 ± 0.2* | −0.02 ± 0.87 | 0.45 ± 0.02 | 0.90 ± 0.05* | 2.90 ± 0.20* | 16.4 ± 1.4* |
Data are means ± SE (12 mice at least for each group except for diabetes/insulin group with 7 mice). BWG, body weight gain; HWR or KWR, ratio of the heart or kidney weight, respectively, to body weight; WBGL, fasting whole-blood glucose level measured from blood samples obtained from tail vein.
* P < 0.05 vs. corresponding control;
† P < 0.05 vs. wild-type diabetic group.