TABLE 1

General parameters of STZ-induced diabetes in wild-type and MT-TG mice

GroupsWBGL (mmol/l)BWG (g)HWR (%)KWR (%)HbA1c (%)Serum TBARS (nmol/ml)
Wild type
    Control4.2 ± 0.31.28 ± 0.360.45 ± 0.020.75 ± 0.042.10 ± 0.0411.0 ± 0.3
    Diabetes15.0 ± 0.3*−0.61 ± 0.650.46 ± 0.050.92 ± 0.05*3.07 ± 0.15*16.6 ± 0.8*
    Diabetes/insulin7.6 ± 1.11.25 ± 0.500.45 ± 0.100.77 ± 0.452.21 ± 0.5612.5 ± 1.3
MT-TG
    Control4.1 ± 0.21.17 ± 0.280.44 ± 0.010.76 ± 0.032.09 ± 0.1212.4 ± 1.0
    Diabetes14.9 ± 0.2*−0.02 ± 0.870.45 ± 0.020.90 ± 0.05*2.90 ± 0.20*16.4 ± 1.4*
  • Data are means ± SE (12 mice at least for each group except for diabetes/insulin group with 7 mice). BWG, body weight gain; HWR or KWR, ratio of the heart or kidney weight, respectively, to body weight; WBGL, fasting whole-blood glucose level measured from blood samples obtained from tail vein.

  • *

    * P < 0.05 vs. corresponding control;

  • P < 0.05 vs. wild-type diabetic group.