TABLE 2

Blood pressure and cardiac function in the mice 2 weeks after STZ treatment

Cardiac function parametersWild type
MT-TG
ControlDiabetesDiabetes/insulinControlDiabetes
n11931010
Blood pressure (mmHg)
    Systolic pressure94.5 ± 5.6102.4 ± 6.797.5 ± 5.694.1 ± 4.795.6 ± 1.0
    Diastolic pressure70.7 ± 8.176.1 ± 5.572.4 ± 6.173.7 ± 3.170.0 ± 8.4
Cardiac function
    Heart rate (bpm)402.3 ± 10.0451.2 ± 18.7*406.0 ± 3.6421.8 ± 7.8434.4 ± 13.1
    LVEDP (mmHg)5.8 ± 1.017.1 ± 3.0*5.7 ± 0.57.7 ± 2.27.8 ± 1.2
    LVMDP (mmHg)−0.6 ± 1.21.5 ± 1.4−0.9 ± 1.0−0.6 ± 2.2−0.7 ± 1.8
    LVPSP (mmHg)103.9 ± 1.998.9 ± 1.6107.6 ± 4.1103.4 ± 4.9103.1 ± 5.6
    Maximum dP/dt (mmHg/s)7,155.7 ± 318.85,054.9 ± 532.8*7,487.1 ± 273.57,311.2 ± 503.87,380.7 ± 702.0
    Maximum dP/dt DCON (ms)37.6 ± 3.433.3 ± 4.940.4 ± 0.636.1 ± 3.837.5 ± 4.1
    τ (ms)20.4 ± 1.829.1 ± 3.9*22.2 ± 0.720.1 ± 1.921.4 ± 3.1
    Embedded Image R (ms)44.3 ± 2.643.0 ± 3.644.8 ± 2.840.9 ± 2.840.3 ± 3.0
  • Data are means ± SE. LVPSP, left ventricular peak systolic pressure; DCON, duration of contraction; τ, time constant of relaxation; Embedded Image R, time constant duration of half-relaxation.

  • *

    * P < 0.05 vs. wild-type control.