TABLE 3

Blood pressure and cardiac function in the mice 6 months after STZ treatment

Cardiac function parametersWild type
MT-TG
DiabetesControlDiabetesControl
Blood pressure
    Systolic pressure (mmHg)94.9 ± 5.895.6 ± 7.092.1 ± 2.794.8 ± 8.4
    Diastolic pressure (mmHg)69.7 ± 3.776.1 ± 5.5*68.9 ± 3.366.6 ± 8.5
Cardiac function
    Heart rate (bpm)382.3 ± 12.9436.5 ± 19.1*386.2 ± 10.4399.2 ± 26.7
    LVEDP (mmHg)8.3 ± 1.818.4 ± 4.8*9.5 ± 2.18.4 ± 1.5
    LVMDP (mmHg)−0.9 ± 2.212.3 ± 5.5*−1.4 ± 3.6−4.9 ± 1.8
    LVPSP (mmHg)98.8 ± 4.093.8 ± 5.2103.2 ± 5.4108.0 ± 4.9
    Maximum dP/dt (mmHg/s)8,262.4 ± 524.74,183.1 ± 1,287.1*8,132.0 ± 675.69,113.6 ± 692.3
    DCON (ms)30.1 ± 4.229.0 ± 6.328.0 ± 2.129.6 ± 5.8
    τ (ms)23.7 ± 2.533.1 ± 4.2*22.0 ± 1.024.2 ± 1.1
    Embedded Image R (ms)45.2 ± 3.640.8 ± 3.745.7 ± 3.747.2 ± 2.2
  • Data are means ± SE (n = 6 or 7). LVPSP, left ventricular peak systolic pressure; DCON, duration of contraction; τ, time constant of relaxation; Embedded Image R, time constant duration of half-relaxation.

  • *

    * P < 0.05 vs. wild-type control.