Microarray hits: oxidative phosphorylation

GeneFold changeBaseline value (%)P
NDUFB3↓ 1.471.4<0.01
NDUFB5↓ 1.952.6<0.01
SDHB↓ 2.441.6<0.01
SLC25A12↓ 1.855.5<0.01
NDUFV1↓ 1.952.6<0.01
NDUFS1↓ 2.441.6<0.01
  • By microarray analysis, 297 genes were up- or downregulated after a HFD. Of those 297, 6 are known to be involved in oxidative phosphorylation or mitochondrial function. NDUFB3, NADH dehydrogenase (ubiquinone) 1β subcomplex, 3; NDUFB5, NADH dehydrogenase (ubiquinone) 1βsubcomplex, 5; NDUFV1, NADH dehydrogenase (ubiquinone) flavoprotein 1; NDUFS1, NADH dehydrogenase (ubiquinone) Fe-S protein 1; SDHB, succinate dehydrogenase complex, subunit B; SLC25A12, solute carrier family 25 (mitochondrial carrier).