TABLE 2

Clinical characteristics of NGT subjects in the different study populations in relation to LARS2 His324Gln polymorphism

Hoorn study
ERGO study
DK2, Inter99 study
HHHQ + QQHHHQ + QQHHHQ + QQ
n32313432254,248253
Age (years)60 ± 761 ± 564 ± 566 ± 5*45.2 ± 7.844.6 ± 7.7
Sex (male/female)128/1954/9238/19411/141,964/2,284130/123
BMI (kg/m2)26.1 ± 3.025.7 ± 2.625.9 ± 3.225.2 ± 4.125.5 ± 4.125.3 ± 3.7
HbA1c (%)5.5 ± 0.45.2 ± 0.45.8 ± 0.55.8 ± 0.75.8 ± 0.45.7 ± 0.4
Fasting glucose (mmol/l)5.4 ± 0.55.1 ± 0.45.4 ± 0.45.4 ± 0.45.3 ± 0.45.3 ± 0.4
2-h glucose (mmol/l)5.2 ± 1.35.1 ± 1.35.3 ± 1.15.4 ± 1.15.5 ± 1.15.5 ± 1.2
Fasting insulin (pmol/l)79 ± 3671 ± 1669 ± 3469 ± 3237 ± 2339 ± 24
2-h insulin (pmol/l)NANA60 ± 5077 ± 56168 ± 131164 ± 124
HOMA-IR19.0 ± 9.816.2 ± 3.717.0 ± 8.816.9 ± 9.08.9 ± 5.79.2 ± 5.7
Cholesterol (mmol/l)6.6 ± 1.16.4 ± 1.16.6 ± 1.06.3 ± 1.25.4 ± 1.05.3 ± 1.0
HDL (mmol/l)1.33 ± 0.341.50 ± 0.651.34 ± 0.331.31 ± 0.371.46 ± 0.401.40 ± 0.37
Triglycerides (mmol/l)1.41 ± 0.671.38 ± 0.581.48 ± 0.621.70 ± 1.031.19 ± 0.951.14 ± 0.79
Free fatty acids (mmol/l)0.58 ± 0.210.55 ± 0.170.29 ± 0.090.34 ± 0.12*NANA
  • Data are means ± SD. Three QQ homozygotes were detected in the DK2 cohort. P values were obtained after general linear regression (SPSS), with age and BMI as covariates and sex and genotype as fixed factors.

  • *

    * P ≤ 0.01,

  • P ≤ 0.05. HOMA-IR, homeostasis model assessment of insulin resistance.