TABLE 1

Potential STAT5 binding sites in the FAS promoter

GenePositionSequencePRL responsive
Consensus GAS/SIETTC NNN GAA
FAS−908 to −893GGG TCC CGG AAA CCA GYes
FASmutant −908GGG TCA AGG AAA CCA GNo
FAS−951 to −931C CCT TTC AAA AGANo
FAS−1,226 to −1,214C TCC TTC CAC AGA GAGNo
FAS−4,639 to −4,621A ACT TTT TGA AACNo
β-Casein−100 to −87G GTT TTC TTG GAA TTYes