TABLE 1

Baseline characteristics

Group 1 (reference)*Group 2 (IMA)Group 3 (TPMA)Group 4 (PMA)§P value (group 2)P value (group 3)P value (group 4)
n9949148
Age (years)17.3 ± 6.415.3 ± 4.816.1 ± 6.317.0 ± 5.10.0600.4780.902
Sex (% male)45%37%50%75%0.3780.7810.148
Age at onset (years)8.7 ± 4.58.3 ± 4.18.5 ± 4.78.0 ± 3.10.6150.8520.682
Disease duration (years)8.6 ± 4.77.0 ± 3.27.6 ± 3.99.0 ± 5.70.0380.4310.809
A1C (%)8.4 ± 1.19.0 ± 1.28.7 ± 1.09.2 ± 1.30.0080.3560.064
Mean AER (μg/min)4.1 ± 1.98.5 ± 6.09.9 ± 6.79.5 ± 8.6<0.001<0.0010.001
Mean systolic blood pressure (mmHg)114 ± 10111 ± 9112 ± 11114 ± 110.1480.6490.936
Mean diastolic blood pressure (mmHg)64 ± 662 ± 662 ± 764 ± 60.0970.3440.977
GFR (ml · min−1 · 1.73 m−2)143 ± 28136 ± 24138 ± 23163 ± 370.1390.5230.042
RPF (ml · min−1 · 1.73 m−2)688 ± 177645 ± 194635 ± 198615 ± 1140.1990.3300.309
Filtration fraction0.22 ± 0.040.23 ± 0.090.23 ± 0.070.25 ± 0.040.2870.5090.114
  • Data are means ± SD. Significant values are in bold. P values result from χ2 analysis for proportion comparisons and one-factor ANOVA for all other variables between each individual group and the reference group.

  • *

    * n in group 1: GFR = 96, RPF and FF = 75.

  • n in group 2: RPF and FF = 46.

  • n in group 3: RPF and FF = 13.

  • §

    § n in group 4: RPF and FF = 7.