TABLE 2

Association studies of the Arg72Thr variant of PYY with overweight, obesity, and type 2 diabetes in Danish whites

GroupnArg/ArgArg/ThrThr/ThrArg allele frequency (95% CI)*Pallele frequency*Pgenotype distribution*PArg/Arg versus Arg/Thr + Thr/Thr (OR [95% CI])
Subjects with BMI <25 kg/m22,6351,149 (43.6)1,196 (45.4)290 (11.0)66.3 (65.0–67.6)
Subjects with 25 ≤ BMI < 30 kg/m22,3521,104 (46.9)985 (41.9)263 (11.2)67.9 (66.5–69.2)0.0960.0370.018 (1.15 [1.02–1.28])
Subjects with BMI ≥30 kg/m21,035476 (46.0)433 (41.8)126 (12.2)66.9 (64.9–68.9)0.620.14
Subjects with BMI ≥25 kg/m23,3871,580 (46.6)1,418 (41.9)389 (11.5)67.6 (66.5–68.7)0.140.0230.019 (1.14 [1.02–1.25])
Glucose-tolerant subjects4,6392,077 (44.8)2,037 (43.9)525 (11.3)66.7 (65.8–67.7)
Type 2 diabetic patients1,326652 (49.2)531 (40.0)143 (10.8)69.2 (67.4–71.0)0.0180.0170.005 (1.19 [1.05–1.35])
  • Data are n (%), unless otherwise indicated. Top four rows:

  • *

    * P values are calculated with χ2 test and describe the significance levels comparing the lean and the overweight, the lean and the obese, and the lean and the overweight + obese groups. Bottom two rows: *P values are calculated with χ2 test and describe the significance levels comparing the glucose-tolerant subjects and the type 2 diabetic patients.