TABLE 3

Association studies of the Arg72Thr variant of PYY with diabetes-related quantitative traits in a population-based cohort of Danish whites

ResponseArg/ArgArg/ThrThr/ThrPArg/Argvs. Arg/Thrvs. Thr/ThrPArg/Arg+ Arg/Thrvs. Thr/ThrPArg/Argvs. Arg/Thr+ Thr/Thr
n (men/women)2,729 (50/50)2,614 (47/53)679 (51/49)
Age (years)45.3 (45.0–46.6)45.9 (45.6–46.2)46.3 (45.7–46.9)
BMI (kg/m2)26.4 (26.2–26.6)26.2 (26.0–26.3)26.4 (26.0–26.7)0.140.690.09
Fasting plasma insulin (pmol/l)*43 (42–44)43 (42–44)43 (41–45)0.670.610.39
Fasting plasma glucose (mmol/l)*5.6 (5.6–5.7)5.6 (5.6–5.7)5.6 (5.5–5.7)0.900.650.96
Plasma glucose 2 h after OGTT (mmol/l)*6.3 (6.2–6.4)6.2 (6.1–6.3)6.1 (5.9–6.2)0.020.010.03
Area under the curve for post-OGTT plasma glucose (mmol/l)*892 (885–898)885 (878–892)875 (862–889)0.060.090.03
Insulinogenic index (insulin)*28.7 (28.0–30.0)30.0 (29.2–30.7)30.5 (29.0–32.0)0.040.160.01
  • Data are means (95% CI), unless otherwise indicated. Means were adjusted for the effect of age, sex, and BMI.

  • *

    * Kubic-transformed before analysis. The insulinogenic index was calculated as fasting serum insulin (pmol/l) subtracted from 30 min post-OGTT serum insulin (pmol/l) and divided by 30 min post-OGTT plasma glucose (mmol/l). The area under the curve for glucose was calculated using the trapezoidal method.