TABLE 3

Acute response of analytes to injection of saline or oxyntomodulin in the treatment group

Day 1 (saline)
Day 2 (oxyntomodulin)
Day 29 (oxyntomodulin)
Initial valueChange at 30 minInitial valueChange at 30 minPInitial valueChange at 30 minP
Insulin (pmol/l)34.5 ± 4.7−6.1 ± 3.227.4 ± 3.632.6 ± 7.70.0004*26.7 ± 4.340.5 ± 10.10.0008*
Glucose (mmol/l)4.79 ± 0.09−0.04 ± 0.064.73 ± 0.100.07 ± 0.080.3004.88 ± 0.090.02 ± 0.070.6629
Ghrelin (pmol/l)370 ± 65−5 ± 23375 ± 74−42 ± 350.3429405 ± 86−49 ± 220.2327
Peptide YY (pmol/l)12.2 ± 2.11.1 ± 2.215.2 ± 4.4−3.5 ± 4.10.337712.1 ± 1.6−2.6 ± 1.30.1637
  • Data are means ± SE. A paired t test was used to compare the change from baseline 30 min after an injection of oxyntomodulin with the change on day 1 when the treatment group injected saline.

  • *

    * Significant difference.