TABLE 1

Baseline characteristics by treatment group

Baseline characteristics*OverallPlaceboMetforminLifestyle
n3,2341,0821,0731079
Female2,191 (67.7)747 (69.0)710 (66.2)734 (68.0)
Race/ethnicity
    Caucasian1,768 (54.7)586 (54.2)602 (56.1)580 (53.8)
    African American645 (19.9)220 (20.3)221 (20.6)204 (18.9)
    Hispanic508 (15.7)168 (15.5)162 (15.1)178 (16.5)
    American Indian171 (5.3)59 (5.5)52 (4.8)60 (5.6)
    Asian American142 (4.4)49 (4.5)36 (3.4)57 (5.3)
Age (years)50.6 ± 10.750.3 ± 10.450.9 ± 10.350.6 ± 11.3
Weight (kg)94.2 ± 20.394.3 ± 20.294.3 ± 19.994.1 ± 20.8
BMI (kg/m2)34.0 ± 6.734.2 ± 6.733.9 ± 6.633.9 ± 6.8
Waist (cm)105.1 ± 14.5105.2 ± 14.3104.9 ± 14.4105.1 ± 14.8
Glucose (mmol/l)
    Fasting5.9 ± 0.55.9 ± 0.55.9 ± 0.55.1 ± 0.4
    30 min9.4 ± 1.49.4 ± 1.39.5 ± 1.49.4 ± 1.4
    120 min9.1 ± 0.99.1 ± 1.09.2 ± 1.09.1 ± 0.9
A1C (%)5.9 ± 0.55.9 ± 0.55.9 ± 0.55.9 ± 0.5
Insulin (pmol/l)
    Fasting186 ± 105185 ± 104188 ± 103184 ± 108
    30 min698 ± 445692 ± 413713 ± 491690 ± 429
ISI0.195 ± 0.1320.192 ± 0.1280.191 ± 0.1250.201 ± 0.142
IGR124.3 ± 92.9122.9 ± 85.8124.9 ± 99.2125.0 ± 93.4
CIR0.634 ± 0.4280.622 ± 0.3700.643 ± 0.4680.638 ± 0.440
Fasting proinsulin (pmol/l)18.2 ± 13.918.2 ± 13.918.3 ± 14.618.0 ± 13.3
  • Data are means ± SD or n (%).

  • *

    * No significant differences among the three treatment groups.