TABLE 3

Partial correlations of changes from baseline to year 1, adjusted for baseline age, sex, and race/ethnicity

WeightProinsulin1/FIISICIRIGRFasting glucoseA1C
Placebo (n = 933)
    Weight1
    Fasting proinsulin0.361
    1/FI−0.30−0.391
    ISI−0.33−0.410.981
    CIR−0.020.02−0.14−0.081
    IGR0.010.03−0.07−0.060.891
    Fasting glucose0.300.32−0.34−0.49−0.28−0.051
    A1C0.220.19−0.11−0.13−0.07−0.020.221
Metformin (n = 937)
    Weight1
    Fasting proinsulin0.331
    1/FI−0.29−0.341
    ISI−0.31−0.350.981
    CIR0.000.03−0.22−0.171
    IGR0.020.05−0.16−0.150.891
    Fasting glucose0.260.31−0.34−0.46−0.24−0.061
    A1C0.260.24−0.16−0.180.000.040.201
Lifestyle (n = 946)
    Weight1
    Fasting proinsulin0.371
    1/FI−0.38−0.381
    ISI−0.40−0.370.981
    CIR−0.070.03−0.15−0.101
    IGR−0.020.03−0.12−0.100.891
    Fasting glucose0.340.31−0.41−0.53−0.26−0.061
    A1C0.350.29−0.23−0.24−0.08−0.040.251
  • Correlations with an absolute value >0.07 (placebo), >0.06 (metformin), and >0.06 (lifestyle) are significant at the 0.05 level, and correlations are adjusted for age, sex, and race/ethnicity. 1/FI, 1/fasting insulin.