TABLE 3

Specific inhibitors of caspase-2, -3, -8, and -9 decreased apoptosis induced by 3,4-DGE

Vehiclez-VDVAD-fmkDEVD-fmkIETD-fmkLEHD-fmk
Control10.5 ± 1.111.2 ± 1.311.4 ± 1.58.2 ± 2.18.4 ± 1.3
3,4-DGE 72 h25.4 ± 2.17.6 ± 1.01*17.5 ± 3.06.6 ± 1.1*5.8 ± 1.08*
  • Data are the means ± SD of four independent experiments (% apoptosis). Hypodiploid cells were quantified by flow cytometry. In all experiments cells were treated with 50 μmol/l 3,4-DGE for 72 h.

  • *

    * P < 0.05 vs. 3,4-DGE alone;

  • P < 0.08 vs. 3,4-DGE alone. z-VDVAD-fmk, benzyloxycarbonyl-Val-Asp-Val-Ala-Asp-fluoromethylketone.