TABLE 1

Summary of central and peripheral treatments in experiment 2

nICV treatmentPeripheral insulinPeripheral leptinPeripheral saline
Normal6aCSF + control IgGNoNoYes
DbX + control6aCSF + control IgGNoNoYes
DbX + GALP7aCSF + 15 nmol/day GALPNoNoYes
DbC + control6aCSF + control IgGYesYesNo
DbC + anti-GALP6aCSF + 2.5 mg/day goat anti-GALPYesYesNo
  • Doses of administered substances: peripheral insulin, 1.0 unit twice daily; peripheral leptin, 2.5 mg/kg twice daily; peripheral saline 0.1 ml twice daily. ICV, intracerebroventricular.