TABLE 2

Results by SNP for case-control–and family-based analyses

SNPAllelesMAFObserved transmissionsExpected transmissionsOR (95% CI)P
Case-control analysis (n = 2,010 case and 1,643 control subjects)
    rs959398A/G0.081.03 (0.88–1.22)0.70
    rs1920792C/T0.471.01 (0.92–1.11)0.77
    A98VT/C0.031.30 (1.01–1.68)0.04
    GE117884_349A/G0.300.98 (0.88–1.08)0.70
    rs3830659 (r2 = 0.97 with I27L)ins/del0.320.96 (0.87–1.06)0.40
    rs1169292T/C0.320.93 (0.84–1.03)0.15
    rs2071190A/T0.241.12 (1.01–1.25)0.04
    P288PC/G0.300.98 (0.88–1.08)0.64
    rs1169306T/C0.370.94 (0.85–1.03)0.18
Family association analysis (n = 521 families)
    rs959398A/G0.0974681.18 (0.81–1.71)0.32
    rs1920792C/T0.462922950.94 (0.77–1.15)0.78
    A98VT/C0.0438381.06 (0.64–1.76)0.95
    GE117884_349A/G0.302022130.89 (0.72–1.11)0.21
    rs3830659 (r2 = 0.97 with I27L)ins/del0.322122140.97 (0.78–1.20)0.67
    rs1169292T/C0.312092091.06 (0.85–1.33)0.99
    rs2071190A/T0.251771830.96 (0.75–1.21)0.63
    P288PC/G0.302092120.98 (0.79–1.22)0.58
    rs1169306T/C0.372402470.95 (0.87–1.04)0.93
  • For case-control results, ORs are given for the first allele in the “Alleles” column. For family-based results, expected statistics and P values obtained from FBAT (27) and ORs from discordant alleles sib test are given. MAF = MAF in control subjects (case-control analysis) and founders (family analysis).