Subject characteristics
| Nondiabetic | Obese | Type 2 diabetic | |
|---|---|---|---|
| n | 8 | 8 | 7 |
| Age (years) | 47.25 ± 4.8 | 43.5 ± 4.0 | 48.0 ± 5.2 |
| Weight (kg) | 75.2 ± 5.4 | 96.7 ± 4.0 | 110.0 ± 5.4 |
| BMI (kg/m2) | 24.4 ± 1.2 | 33.3 ± 1.06* | 37.1 ± 2.64* |
| Fasting plasma glucose (mmol/l) | 5.09 ± 0.12 | 5.1 ± 0.1 | 11.3 ± 1.5* |
| Glucose infusion rate (mg · kg−1 · min−1) | 9.9 ± 0.93 | 7.0 ± 0.37† | 2.26 ± 0.76* |
| Basal insulin (pmol/l) | 66.7 ± 10 | 125.36 ± 26‡ | 315 ± 78‡ |
| Insulin after 300-min clamping (pmol/l) | 1,070 ± 47 | 1,290 ± 96 | 1,090 ± 74 |
| Basal plasma free fatty acids (μmol/l) | 346 ± 36 | 400 ± 30§ | 750 ± 120‡ |
| Free fatty acids after insulin clamping (μmol/l) | 19 ± 3.8 | 16 ± 3.5 | 270 ± 100 |
| Triacylglycerol (mg/dl) | 88.75 ± 6.8 | 128.6 ± 21‖ | 390 ± 127† |
Data are means ± SE. All P values were determined by comparing with nondiabetic subjects.
* P < 0.005;
† P < 0.05;
‡ P < 0.02;
§ NS;
‖ P = 0.05.