TABLE 1

Metabolic characteristics and β-cell replication rates of 1-year-old mice treated with seven daily injections of low-dose streptozotocin (30 mg · kg−1 · body wt−1)

TreatmentnAge
Body weight
Blood glucose
BrdU β-cells
Initial (days)EndInitial (g)EndInitial (mg/dl)PeakEndTotal (%)Per day (%)
Control3304 ± 17323 ± 1749.3 ± 9.549.4 ± 9.2124 ± 11147 ± 11140 ± 141.4 ± 0.20.080 ± 0.016
Streptozotocin3297 ± 40316 ± 4052.1 ± 3.940.2 ± 3.1131 ± 26281 ± 86189 ± 214.1 ± 9.00.930 ± 0.528
  • Data are the means ± SE for three mice per group. Pancreatic β-cell replication rates are the percent BrdU-positive total β-cells or percent BrdU total β-cells per day.