TABLE 1

Fasting blood glucose and UAE in diabetic and control mice

StrainGlycemic statusBefore STZWeeks after STZ or vehicle
51525
C57BL/6J
    FBS (mg/dl)DM170.0 ± 11.2 (10)424.9 ± 33.9 (9)*502.5 ± 31.2 (21)*506.6 ± 46.0 (18)*
CN170.0 ± 3.7 (10)170.4 ± 7.1 (5)164.8 ± 4.7 (5)157.4 ± 8.1 (5)
    A1C (%)DM3.8 ± 0.2 (3)NA8.2 ± 0.4 (21)*9.4 ± 0.6 (11)*
CN3.6 ± 0.1 (5)NA4.1 ± 0.1 (5)*3.8 ± 0.1 (5)
    BW (g)DM21.3 ± 0.4 (10)25.6 ± 0.6 (9)*25.6 ± 0.7 (21)*26.9 ± 0.8 (18)*
CN20.3 ± 0.2 (5)26.7 ± 1.2 (5)*28.9 ± 0.9 (5)*29.2 ± 1.4 (5)*
    ACR (μg/mg)DM36.9 ± 7.6 (9)35.4 ± 5.7 (9)29.5 ± 12.4 (16)*72.1 ± 20.4 (16)
CN45.6 ± 12.4 (5)20.1 ± 1.6 (5)48.11 ± 16.5 (5)53.2 ± 24.3 (5)
DBA/2J
    FBS (mg/dl)DM160.5 ± 8.6 (15)485.8 ± 31.3 (19)*485.3 ± 27.4 (21)*511.3 ± 75.6 (6)*
CN165.2 ± 16.2 (5)127.4 ± 15.5 (5)*148.6 ± 8.5 (5)152.6 ± 4.5 (5)
    A1C (%)DM2.9 ± 0.1 (3)NA6.7 ± 0.1 (21)*13.4 ± 0.8 (6)*
CN2.8 ± 0.1 (5)NA2.8 ± 0.1 (5)2.7 ± 0.2 (5)
    BW (g)DM23.4 ± 0.6 (15)22.3 ± 0.7 (19)20.8 ± 0.7 (21)*18.7 ± 0.9 (10)*
CN22.2 ± 0.9 (6)28.2 ± 0.8 (4)*29.5 ± 1.2 (4)*30.1 ± 0.9 (5)*
    ACR (μg/mg)DM26.6 ± 6.6 (29)424.4 ± 89.4 (24)*608.0 ± 220.8 (15)*§421.4 ± 167.3 (11)*§
CN19.7 ± 5.1 (5)48.7 ± 7.0 (9)*71.1 ± 15.2 (7)*65.8 ± 13.2 (7)*
A/J
    FBS (mg/dl)DM154.4 ± 4.4 (15)360.8 ± 28.0 (10)*505.6 ± 31.4 (22)*391.6 ± 50.6 (16)*
CN159.8 ± 7.8 (5)146.0 ± 13.4 (4)157.0 ± 4.0 (4)171.0 ± 2.1 (4)
    A1C (%)DM2.6 ± 0.03 (9)NA5.1 ± 0.1 (22)*4.1 ± 0.2 (16)*
CN2.6 ± 0.03 (5)NA2.6 ± 0.04 (5)2.6 ± 0.04 (5)
    BW (g)DM23.4 ± 0.6 (15)18.3 ± 0.6 (10)*20.5 ± 0.8 (27)*23.2 ± 0.7 (16)
CN22.9 ± 0.6 (5)26.8 ± 0.8 (4)*28.2 ± 0.9 (4)*30.6 ± 1.3 (5)*
    ACR (μg/mg)DM26.6 ± 12.2 (23)119.5 ± 21.1 (27)*174.0 ± 48.2 (17)*64.0 ± 12.6 (15)*
CN18.7 ± 2.2 (5)54.5 ± 14.2 (5)*88.4 ± 25.8 (4)*81.2 ± 8.8 (4)*
FVB/NJ
    FBS (mg/dl)DM141.8 ± 12.4 (12)576.0 ± 43.0 (8)*549.4 ± 52.1 (10)*610.0 ± 23.3 (5)*
CN134.0 ± 19.8 (4)169.5 ± 2.5 (4)148.3 ± 19.8 (4)151.0 ± 12.1 (4)
    A1C (%)DM3.0 ± 0.1 (7)NA5.8 ± 0.2 (10)*5.0 ± 0.3 (5)*
CNNANA3.0 ± 0.2 (4)NA
    BW (g)DM27.9 ± 0.8 (12)26.8 ± 0.3 (8)27.4 ± 0.6 (10)33.0 ± 0.5 (5)*
CN26.7 ± 2.0 (4)29.0 ± 2.2 (4)30.0 ± 2.1 (4)33.1 ± 1.8 (4)
    ACR (μg/mg)DM61.6 ± 13.2 (7)6.1 ± 1.4 (9)*88.0 ± 21.3 (12)89.3 ± 27.7 (7)
CN45.4 ± 18.5 (4)74.1 ± 21.7 (4)NA63.0 ± 31.0 (4)
MRL/MpJ
    FBS (mg/dl)DM120.8 ± 6.6 (5)434.8 ± 22.7 (19)*493.5 ± 21.9 (17)*428.0 ± 45.1 (5)*
CN140.5 ± 4.8 (4)165.0 ± 3.7 (4)155.0 ± 12.4 (4)153.5 ± 20.2 (4)
    A1C (%)DM3.0 ± 0.1 (5)5.3 ± 0.1 (19)6.9 ± 0.2 (8)*6.1 ± 0.2 (5)*
CN3.0 ± 0.1 (4)NA3.6 ± 0.2 (4)3.3 ± 0.4 (4)
    BW (g)DM37.1 ± 0.4 (5)34.0 ± 0.8 (19)*36.7 ± 0.6 (17)37.0 ± 1.4 (5)
CN35.7 ± 1.4 (4)36.5 ± 2.6 (4)38.6 ± 3.7 (4)39.2 ± 4.3 (4)
    ACR (μg/mg)DM74.4 ± 17.0 (14)95.2 ± 43.4 (20)122.5 ± 32.7 (18)87.7 ± 22.3 (6)
CN39.5 ± 14.2 (4)73.2 ± 14.5 (4)18.0 ± 7.5 (4)43.2 ± 14.0 (4)
KK/HlJ
    FBS (mg/dl)DM160.6 ± 7.4 (15)297.5 ± 30.6 (15)*321.3 ± 23.0 (19)*330.0 ± 32.8 (13)*
CN142.0 ± 5.2 (5)157.4 ± 9.3 (10)158.8 ± 6.8 (10)156.8 ± 10.9 (10)
    A1C (%)DM4.5 ± 0.1 (15)NA6.4 ± 0.4 (19)*6.4 ± 0.5 (13)*
CN4.7 ± 0.2 (5)NA4.8 ± 0.2 (10)4.0 ± 0.1 (8)*
    BW (g)DM31.4 ± 1.0 (25)29.8 ± 0.7 (15)30.9 ± 0.6 (19)32.3 ± 0.8 (13)
CN31.4 ± 1.5 (7)33.8 ± 1.5 (5)36.6 ± 1.4 (10)*35.9 ± 1.1 (13)*
    ACR (μg/mg)DM72.9 ± 12.1 (13)509.9 ± 87.6 (19)*586.9 ± 84.9 (19)*§635.8 ± 122.0 (13)*§
CN72.8 ± 11.4 (14)177.0 ± 50.7 (10)224.4 ± 80.8 (10)*349.1 ± 39.7 (10)*
  • Data are means ± SE (no. of animals).

  • *

    * P < 0.05 vs. baseline at same group;

  • P < 0.05 vs. age-matched controls at same time point;

  • P < 0.05 vs. all other diabetic strains at same time point;

  • §

    § P < 0.05 vs. diabetic C57BL/6J, A/J, FVB/NJ, and MRL/MpJ mice;

  • P < 0.001 vs. A1C in all other diabetic strains except FVB/NJ strain at same time point;

  • P < 0.05 vs. FBS in diabetic C57BL/6J, DBA/2J, and FVB/NJ mice at same time point. BW, body weight; CN, control mice; DM, diabetic mice; FBS, fasting blood glucose; NA, not available.