TABLE 2

Temporal pattern of GFR in STZ-induced diabetic and control inbred mice

StrainBefore STZWeeks after STZ or vehicle
51525
C57BL/6J
    Diabetic217.2 ± 13.7 (18)300.6 ± 24.2 (13)*275.4 ± 31.7 (12)*345.5 ± 24.5 (9)*
    Control207.5 ± 18.7 (12)306.0 ± 47.2 (8)*244.3 ± 37.9 (4)325.9 ± 17.6 (5)*
DBA/2J
    Diabetic220.6 ± 22.7 (20)365.5 ± 30.4 (23)*451.9 ± 62.8 (8)*369.9 ± 43.0 (12)*
    Control246.3 ± 35.1 (8)457.5 ± 23.2 (3)*452.2 ± 121.5 (3)*473.9 ± 29.4 (12)*
A/J
    Diabetic261.2 ± 23.6 (16)246.7 ± 27.3 (15)288.7 ± 20.6 (10)287.5 ± 28.6 (15)
    Control271.5 ± 47.4 (4)378.5 ± 32.8 (4)393.6 ± 13.8 (4)301.0 ± 80.6 (4)
FVB/NJ
    Diabetic254.4 ± 26.3 (16)479.3 ± 64.8 (11)*562.8 ± 40.0 (4)*822.6 ± 84.9 (7)*§
    Control260.2 ± 43.9 (7)245.7 ± 58.8 (4)302.4 ± 15.2 (4)NA
MRL/MpJ
    Diabetic239.8 ± 72.9 (7)309.6 ± 36.2 (14)491.5 ± 69.3 (8)*479.1 ± 49.9 (7)*
    Control300.3 ± 118.6 (4)NA302.3 ± 31.7 (4)272.3 ± 25.6 (4)
KK/HlJ
    Diabetic269.3 ± 28.9 (12)353.6 ± 24.6 (17)*285.6 ± 19.5 (15)315.4 ± 37.2 (10)
    Control261.4 ± 32.6 (8)286.0 ± 26.8 (4)483.0 ± 64.6 (6)*307.7 ± 39.3 (17)§
  • Data are means ± SE (μl/min) (no. of animals). NA, not available.

  • *

    * P < 0.05 vs. GFR before STZ injection;

  • P < 0.05 vs. controls at same time point;

  • P < 0.05 vs. GFR at 5 weeks after STZ;

  • §

    § P < 0.05 vs. GFR at 15 weeks after STZ.