In vitro effects of IL-6 on insulin resistance in adipocyte cell lines

Effect of IL-6 on insulin sensitivity (ref. no.)Negative effect on insulin sensitivity
Short-term IL-6 treatment enhances glucose transport, and the effect is additive to insulin-stimulated glucose transport (59).*No
IL-6 decreases IRS-1 protein expression and insulin-stimulated tyrosine phosphorylation and reduces insulin-stimulated glucose transport (60).*Yes
IL-6 decreases protein expression of the IR-β subunit and IRS-1 and inhibits insulin-induced activation of IR-β, protein kinase B, and ERK-1/2. It further suppresses insulin-induced lipogenesis and glucose transport by reducing expression of GLUT4 (61).*Yes
IL-6 induces the expression of SOCS-3 (61,62).*Yes
IL-6 decreases adiponectin gene expression and secretion in a dose- and time-dependent manner (63).*Yes
  • Investigated cell lines:

  • *

    * 3T3-L1 adipocytes,

  • 3T3-F442A adipocytes. Protein kinase B is also known as Akt. IR, insulin receptor.