TABLE 3

Association of IL-8 with type 2 diabetes and IGT (multiple logistic regression models)

IL-8 (pg/ml)Quartile 1 (≤10.03)Quartile 2 (>10.03/≤13.48)Quartile 3 (>13.48/≤16.88)Quartile 4 (>16.88)P for trend
Type 2 diabetes vs. control subjects
Model 11.02.30 (1.20–4.41)*3.26 (1.75–6.09)5.98 (3.28–10.90)< 0.0001
Model 21.02.55 (1.26–5.18)2.92 (1.48–5.75)5.76 (3.00–11.07)< 0.0001
Model 31.01.99 (0.95–4.18)2.89 (1.43–5.86)4.98 (2.50–9.89)< 0.0001
Model 41.01.93 (0.90–4.15)2.74 (1.33–5.67)4.69 (2.32–9.50)< 0.0001
IGT vs. control subjects
Model 11.00.84 (0.51–1.40)0.92 (0.56–1.52)0.97 (0.59–1.59)NS
Model 21.00.86 (0.51–1.46)0.86 (0.51–1.45)0.97 (0.58–1.62)NS
Model 31.00.82 (0.47–1.43)0.84 (0.49–1.45)0.92 (0.54–1.58)NS
Model 41.00.79 (0.45–1.40)0.85 (0.49–1.48)0.87 (0.50–1.52)NS
  • Data are ORs (95% CI) for association of type 2 diabetes or IGT with IL-8. Quartiles are based on data from normoglycemic control subjects.

  • *

    * P < 0.05,

  • P < 0.001,

  • P < 0.01, compared with quartile 1. Model 1: crude; model 2: adjusted for BMI; model 3: adjusted for BMI, sex, age, hypertension, LDL cholesterol, HDL cholesterol, and uric acid; model 4: model 3 with additional adjustment for log-CRP and log–IL-6.