TABLE 5

Relationship between early growth and estimates of insulin secretion and insulin resistance in the men and women in the Hertfordshire study

Birth weight
Weight at 1 year
UnadjustedAdjusted*UnadjustedAdjusted*
Men
    HOMA resistance−2.2 (NS)−5.6 (P = 0.02)−3.4 (NS)−4.3 (NS)
    HOMA secretion−0.1 (NS)−2.9 (NS)1.0 (NS)1.0 (NS)
Women
    HOMA resistance−8.3 (P = 0.001)−9.4 (P = <0.001)1.0 (NS)−1.1 (NS)
    HOMA secretion−4.0 (P = 0.05)−4.5 (P = 0.02)1.0 (NS)1.0 (NS)
  • The table shows the percentage change in insulin secretion or insulin resistance per SD increase in birth weight or weight at 1 year of age conditional on birth weight.

  • *

    * Adjusted for age, BMI, smoking, alcohol consumption, and current social class.