TABLE 1

Plasma hormones and metabolites during the hyperinsulinemic-euglycemic clamp in humans with (rhIL-6) and without (control) IL-6 infusion

Basal60 min120 min180 min240 min
Insulin (pmol/l)
    Control34 ± 5586 ± 35*538 ± 26*546 ± 30*532 ± 28*
    rhIL-637 ± 5561 ± 41*540 ± 21*530 ± 17*512 ± 21*
Glucagon (ng/ml)
    Control56 ± 853 ± 1554 ± 1553 ± 1387 ± 17
    rhIL-643 ± 841 ± 637 ± 750 ± 860 ± 12
Epinephrine (nmol/l)
    Control0.22 ± 0.030.17 ± 0.020.19 ± 0.020.20 ± 0.040.21 ± 0.04
    rhIL-60.39 ± 0.090.32 ± 0.070.28 ± 0.080.25 ± 0.050.31 ± 0.09
Norpinephrine (nmol/l)
    Control1.05 ± 0.301.24 ± 0.231.33 ± 0.161.18 ± 0.201.07 ± 0.27
    rhIL-60.89 ± 0.131.19 ± 0.231.08 ± 0.120.99 ± 0.081.06 ± 0.10
Glucose (mmol/l)
    Control4.6 ± 0.14.5 ± 0.14.4 ± 0.14.4 ± 0.14.4 ± 0.1
    rhIL-64.4 ± 0.14.5 ± 0.14.4 ± 0.14.5 ± 0.14.3 ± 0.1
FFA (μmol/l)
    Control558 ± 57195 ± 14*165 ± 15*151 ± 15*151 ± 12*
    rhIL-6522 ± 80188 ± 18*171 ± 17*162 ± 19*159 ± 17*
Lactate (mmol/l)
    Control0.7 ± 0.61.1 ± 0.11.1 ± 0.11.1 ± 0.21.1 ± 0.2
    rhIL-61.0 ± 0.11.2 ± 0.11.1 ± 0.11.0 ± 0.11.1 ± 0.1
Glycerol (μmol/l)
    Control55 ± 736 ± 6*36 ± 6*28 ± 6*28 ± 5*
    rhIL-646 ± 738 ± 7*30 ± 4*33 ± 8*30 ± 7*
  • Data are means ± SE (n = 7).

  • *

    * Difference (P < 0.05) from basal.