TABLE 2

Effects of 5 days’ immunoneutralization of endogenous glucagon in male ob/ob mice

Insulin (pmol/l)Lactate (mmol/l)FFAs (mmol/l)Triglycerides (mmol/l)Liver glycogen (μmol glucosyl units/g liver)
Control mAbs8,157 ± 1,2904.6 ± 0.20.54 ± 0.052.58 ± 0.28259 ± 22
Glucagon mAbs6,375 ± 1,1444.8 ± 0.20.53 ± 0.051.36 ± 0.10*224 ± 21
Lean untreated39.7 ± 7.43.5 ± 0.2*0.50 ± 0.030.93 ± 0.03192 ± 16
  • Data are means ± SE, n = 10 mice/group.

  • *

    * P < 0.01,

  • P < 0.0001,

  • P < 0.05 vs. control mAbs.