TABLE 3

Effects of 14 days’ immunoneutralization of endogenous glucagon in male ob/ob mice

GroupWater intake (g · mouse−1 · 24 h−1)*Food intake (g · mouse−1 · 24 h−1)*ΔBody weight (g)Pre-A1C (%)Post-A1C (%)ΔA1C (%)
Control mAbs11.3 ± 1.412.3 ± 1.6−0.6 ± 0.56.8 ± 0.38.1 ± 0.41.3 ± 0.2
Glucagon mAbs7.5 ± 0.313.8 ± 1.02.7 ± 0.26.8 ± 0.27.1 ± 0.20.3 ± 0.1
  • Data are means ± SE, n = 10 mice/group.

  • *

    * Water and food intake were measured over 24 h after 10 days treatment with the antibodies;

  • P < 0.05,

  • P < 0.001 vs. control mAbs (Student’s t test).