TABLE 1

Genotypic and allelic distribution of the BBS SNPs associated with childhood and/or adult obesity

CohortsGenotype number (frequency)
Allelic POdds ratio (95% CI)
123
BBS2_rs4784675GGGCCC
    Control subjects971 (0.76)277 (0.22)23 (0.02)
    Class 1 and 2 adult obese428 (0.69)173 (0.28)18 (0.03)0.0005*1.39 (1.15–1.69)
    Class 3 adult obese483 (0.71)176 (0.26)20 (0.03)0.0061.30 (1.08–1.57)
    Obese children438 (0.72)156 (0.26)11 (0.02)0.091.18 (0.97–1.44)
BBS4_rs7178130GGGAAA
    Control subjects488 (0.40)552 (0.45)178 (0.15)
    Class 1 and 2 adult obese266 (0.44)277 (0.45)68 (0.11)0.0390.86 (0.74–0.99)
    Class 3 adult obese292 (0.46)262 (0.41)80 (0.13)0.010.84 (0.73–0.97)
    Obese children259 (0.46)256 (0.46)46 (0.08)0.0003*0.76 (0.65–0.88)
BBS6_rs6108572AAATTT
    Control subjects458 (0.37)578 (0.46)217 (0.17)
    Class 1 and 2 adult obese221 (0.36)287 (0.46)110 (0.18)0.711.03 (0.89–1.18)
    Class 3 adult obese225 (0.33)325 (0.48)130 (0.19)0.111.11 (0.97–1.27)
    Obese children190 (0.32)278 (0.46)131 (0.22)0.0071.21 (1.05–1.39)
BBS6_rs221667CCCGGG
    Control subjects806 (0.63)415 (0.33)50 (0.04)
    Class 1 and 2 adult obese374 (0.61)211 (0.34)28 (0.05)0.281.10 (0.93–1.29)
    Class 3 adult obese394 (0.58)250 (0.37)37 (0.05)0.011.23 (1.05–1.44)
    Obese children337 (0.57)216 (0.36)42 (0.07)0.0007*1.33 (1.13–1.56)
  • *

    * Significant P values after simple Bonferroni correction for 36 tests (3 populations × 12 SNPs).