Genotypic and allelic distribution of the BBS SNPs associated with childhood and/or adult obesity
| Cohorts | Genotype number (frequency) | Allelic P | Odds ratio (95% CI) | ||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | |||||
| BBS2_rs4784675 | GG | GC | CC | ||||
| Control subjects | 971 (0.76) | 277 (0.22) | 23 (0.02) | — | — | ||
| Class 1 and 2 adult obese | 428 (0.69) | 173 (0.28) | 18 (0.03) | 0.0005* | 1.39 (1.15–1.69) | ||
| Class 3 adult obese | 483 (0.71) | 176 (0.26) | 20 (0.03) | 0.006 | 1.30 (1.08–1.57) | ||
| Obese children | 438 (0.72) | 156 (0.26) | 11 (0.02) | 0.09 | 1.18 (0.97–1.44) | ||
| BBS4_rs7178130 | GG | GA | AA | ||||
| Control subjects | 488 (0.40) | 552 (0.45) | 178 (0.15) | — | — | ||
| Class 1 and 2 adult obese | 266 (0.44) | 277 (0.45) | 68 (0.11) | 0.039 | 0.86 (0.74–0.99) | ||
| Class 3 adult obese | 292 (0.46) | 262 (0.41) | 80 (0.13) | 0.01 | 0.84 (0.73–0.97) | ||
| Obese children | 259 (0.46) | 256 (0.46) | 46 (0.08) | 0.0003* | 0.76 (0.65–0.88) | ||
| BBS6_rs6108572 | AA | AT | TT | ||||
| Control subjects | 458 (0.37) | 578 (0.46) | 217 (0.17) | — | — | ||
| Class 1 and 2 adult obese | 221 (0.36) | 287 (0.46) | 110 (0.18) | 0.71 | 1.03 (0.89–1.18) | ||
| Class 3 adult obese | 225 (0.33) | 325 (0.48) | 130 (0.19) | 0.11 | 1.11 (0.97–1.27) | ||
| Obese children | 190 (0.32) | 278 (0.46) | 131 (0.22) | 0.007 | 1.21 (1.05–1.39) | ||
| BBS6_rs221667 | CC | CG | GG | ||||
| Control subjects | 806 (0.63) | 415 (0.33) | 50 (0.04) | — | — | ||
| Class 1 and 2 adult obese | 374 (0.61) | 211 (0.34) | 28 (0.05) | 0.28 | 1.10 (0.93–1.29) | ||
| Class 3 adult obese | 394 (0.58) | 250 (0.37) | 37 (0.05) | 0.01 | 1.23 (1.05–1.44) | ||
| Obese children | 337 (0.57) | 216 (0.36) | 42 (0.07) | 0.0007* | 1.33 (1.13–1.56) | ||
* Significant P values after simple Bonferroni correction for 36 tests (3 populations × 12 SNPs).