TABLE 1

Clinical characteristics of study samples

SampleSex (M/F)Age (years)BMI (kg/m2)Fasting plasma glucose (mmol/l)Plasma glucose at 2-h OGTT (mmol/l)Reference
Scandinavian trios
    Diabetes/IGT/IFG176/15739 ± 927 ± 57.2 ± 2.68.5 ± 2.94
    NGT187/19231 ± 1024 ± 55.2 ± 0.55.6 ± 1.1
Scandinavian C/C
    Diabetes/sIGT247/21261 ± 1028 ± 59.8 ± 3.415.0 ± 5.34
    NGT247/21260 ± 1026 ± 46.2 ± 1.86.8 ± 2.8
Swedish C/C
    Diabetes/sIGT267/24766 ± 1228 ± 48.5 ± 2.5ND*5
    NGT267/24766 ± 1228 ± 44.8 ± 0.7ND
Genomics Collaborative Poland C/C
    Diabetes422/58762 ± 1030 ± 58.9 ± 4.0ND6
    NGT422/58759 ± 726 ± 44.8 ± 1.2ND
Genomics Collaborative U.S. C/C
    Diabetes644/58263 ± 1133 ± 79.8 ± 3.0ND6
    NGT644/58261 ± 1027 ± 55.1 ± 0.9ND
Botnia C/C
    Diabetes101/12165 ± 1028 ± 49.1 ± 2.814.7 ± 5.1New
    NGT101/12157 ± 1027 ± 45.2 ± 0.55.2 ± 1.4
Swedish/Finnish C/C
    Diabetes63/7066 ± 1028 ± 49.6 ± 3.116.3 ± 4.4New
    NGT63/7055 ± 926 ± 45.3 ± 0.65.6 ± 1.0
Swedish/Finnish sibs
    Diabetes57/4960 ± 1130 ± 510.8 ± 3.715.2 ± 4.8New
    NGT40/6661 ± 1227 ± 45.3 ± 0.46.1 ± 1.0
Botnia sibs
    Diabetes55/7564 ± 1228 ± 59.0 ± 2.714.8 ± 5.3New
    NGT56/7462 ± 1226 ± 45.5 ± 0.56.1 ± 1.2
  • Data are means ± SD. Plasma glucose was measured at fasting and 2 h after an OGTT.

  • *

    * HbA1c (A1C) = 6.5 ± 1.5%;

  • A1C = 7.9 ± 1.3%;

  • A1C = 8.0 ± 3.1%. C/C, case/control subjects; ND, not determined; sIGT, severe IGT.