TABLE 2

Association of TCF7L2 SNP rs7903146 with risk of type 2 diabetes and model-free estimates of genotype relative risks

AlleleOR (95% CI)P
Total sample*T1.40 (1.30–1.50)6.74 × 10−20
Case/control subjects onlyT1.39 (1.29–1.50)1.55 × 10−17

Genotype
Genotype relative risks (95% CI)
P
HeterozygotesTC vs. CC1.40 (1.27–1.55)3.22 × 10−11
HomozygotesTT vs. CC1.86 (1.55–2.23)1.38 × 10−11
Homozygotes vs. HeterozygotesTT vs. TC1.30 (1.08–1.57)0.00269
  • Genotype relative risks are relative to noncarriers or to heterozygote carriers as indidcated. One-tailed P value:

  • *

    * results from all 9 samples or

  • 6 case-control samples combined by Mantel-Haenszel meta-analysis.