TABLE 3

Association of rs7903146 with type 2 diabetes in each subsample

SamplenOR (95% CI)One-tailed P valueMAF
Case-control group
    Scandinavian9461.27 (1.03–1.58)0.02770.23
    Swedish9661.45 (1.18–1.77)2.84 × 10−40.28
    Genomics Collaborative Polish1,9421.38 (1.20–1.59)1.04 × 10−50.27
    Genomics Collaborative U.S.2,2461.45 (1.27–1.64)1.54 × 10−80.32
    Botnia4301.47 (1.06–2.03)0.01950.22
    Swedish/Finnish2601.02 (0.69–1.51)0.9210.25
    All*6,7901.39 (1.29–1.50)1.55 × 10−170.25
Family-based group
    Botnia sibs2601.83 (0.75–1.63)0.0863
    Swedish/Finnish sibs2121.56 (0.84–2.91)0.160
    Scandinavian trios7561.42 (1.09–1.86)0.0101
    All1,2281.48 (1.17–1.87)4.69 × 10−4
Combined (all samples)*8,0181.40 (1.30–1.50)6.74 × 10−20
  • *

    * Data combined by Mantel-Haenszel meta-analysis; no heterogeneity was observed (P = 0.60 by Breslow Day test).

  • Diabetes trios (n = 91) OR 1.79 (95% CI 1.09–2.93) (P = 0.02); impaired fasting glucose trios (n = 163) 1.43 (0.98–2.09) (P = 0.06); IGT trios (n = 36) 1.18 (0.53–2.64) (P = 0.68). MAF, minor allele frequency.