TABLE 4

Mean trait values by genotype

PhenotypenMean trait values (±SD) by genotype
Two-tailed P value
TTCTCCAdditiveRecessiveTT vs. CCTT vs. TCTC vs. CC
BMI (kg/m2)8,25828.4 ± 5.428.4 ± 5.328.2 ± 5.20.31
n99542322631
    Ins index (mU/mmol)10.9 ± 12.716.5 ± 50.518.1 ± 33.10.00300.00100.00090.00310.3767
    Disp index (mU2/l2)22.5 ± 28.935.8 ± 112.942.6 ± 79.90.00440.00110.00120.00190.6278
    Fasting insulin (mU/l)7.27 ± 4.249.19 ± 6.668.94 ± 6.020.34230.14050.15370.13400.7685
    HOMA-IR (mmol · mU/l2)1.88 ± 1.292.30 ± 2.062.19 ± 1.630.25610.12860.15900.10070.5191
n72127236454
    AUCins*3,911 ± 3,6584,971 ± 3,1765,229 ± 3,2480.00070.00040.00020.00480.1250
    AUCglu*339.8 ± 262.8271.4 ± 214.5270.0 ± 195.30.17750.08410.07780.12660.9297
    AUCins/AUCglu*23.46 ± 39.7524.33 ± 71.0632.14 ± 243.050.00230.00250.00150.01350.1640
  • Traits were log transformed.

  • *

    * Four negative values of AUCins were removed, and 26 negative values of AUCins/AUCglu were removed. Insulin and glucose units used for all calculations were mU/l and mmol/l, respectively. AUC, AUC during OGTT; Disp index, insulin disposition index; Ins index, insulinogenic index.