TABLE 1

Clinical and histological characteristics of reference biopsies analyzed by oligonucleotide array–based gene expression profiling and real-time RT-PCR

Sample nameSexAge (years)Histology major diagnosisHistology scoreCreatinine (mg/dl)Urine proteinuria (g/day)
Living donor
    Array
        LD1F66LDxNA<1.1<0.2
        LD2M26LDx w/o prev. damageNA0.9<0.2
        LD3M49LDx w/o prev. damageNA<1.1<0.2
    Mean ± SEM47 ± 9.6<0.2
    RT-PCR
        LD4F35LDxNA<1.1<0.2
        LD5M39LDxNA<1.1<0.2
        LD6F55LDxNA<1.1<0.2
        LD7M41LDxNA<1.1<0.2
        LD8M61LDxNA<1.1<0.2
        LD9F58LDxNA<1.1<0.2
        LD10M27LDxNA<1.1<0.2
        LD11F54LDxNA<1.1<0.2
        LD12F61LDxNA<1.1<0.2
    Mean ± SEM48 ± 14<1.1<0.2
Cadaveric donor
    Array
        CD1M50CDx, minor int. fibrosisNA0.9<0.2
        CD2M54CDx w/o prev. damageNA0.9<0.2
        CD3M61CDx w/o prev. damageNA1.2<0.2
        CD4F51CDx, minor int. fibrosisNA0.7<0.2
    Mean ± SEM54 ± 2.10.9 ± 0.1<0.2
    RT-PCR
        CD5NANACDxNA<1.1<0.2
MCD/ no histological changes
    Array
        MCD1M32Minimal-change GN11.311.0
        MCD2F32Minimal-change GN10.73.0
        MCD3M16Minimal-change GN01.25.4
        MCD4M20Minimal-change GN in remission00.90.2
    Mean ± SEM25 ± 3.61.0 ± 0.24.9 ± 2.3
    RT-PCR
        MCD5F57Minimal-change GN01.110
        MCD6M33Minimal-change GN11.49.1
        MCD7M24No histological changes00.60.4
    Mean ± SEM38 ± 81.0 ± 0.26.5 ± 2.5