TABLE 2

Clinical and histological characteristics of disease biopsies analyzed by oligonucleotide array–based gene expression profiling and real-time RT-PCR

Sample nameSexAge (years)Histology major diagnosisHistology scoreCreatinine (mg/dl)Proteinuria (g/day)Diabetes typeDiabetes duration (years)HbA1c (%)Retinopathy
DN
    Array
        DN1M45DN00.90.720.37.1No
        DN2F34DN11.40.3131NAYes
        DN3M57DN31.69.71208.7Yes
        DN4M61DN21.13.7235.7Yes
        DN5F46DN22.40.42257.5Yes
        DN6F67DN44.82.425NAYes
        DN7M73DN21.12.4217.3No
        DN8M62DN21.22.5255.6No
        DN9M67DN24.03.02NANANA
        DN10M62DN32.35.0247.8No
        DN11M68DN33.52.4247.2No
        DN14F70DN44.05.0No
        DN15M46DN30.96.0No
    Mean ± SEM58.3 ± 3.42.2 ± 0.43.3 ± 0.710.9 ± 3.47.1 ± 0.3
    RT-PCR
        DN3M57DN31.69.71208.7Yes
        DN5F46DN22.40.42257.5Yes
        DN6F67DN44.82.425NANA
        DN10M62DN32.35.0247.8Yes
        DN11M68DN33.52.4247.2No
        DN16M58DN21.70.726.57.4No
        DN17M78DN43.63.1232NANo
        DN18F59DN43.221.4212NANA
        DN19M58DN42.414.22319.8Yes
        DN20F63DN43.37.02187.9No
        DN21M63DN42.18.62107.1No
        DN22F47DN47.0NA2813.8Yes
        DN23M74DN32.50.3284.6No
        DN24F63DN32.96.5276.4No
        DN25M55DN42.87.5267.8Yes
        DN26M57DN31.61.42208.8NA
        DN27M63DN23.00.6266.2NA
        DN28M66DN29.81.72106.0No
        DN29M60DN42.22.0286.9No
        DN30M75DN21.76.2267.3No
        DN31MNADNNA1.210.02<1NANA
        DN32F63DN42.05.52236.4NA
    Mean ± SEM62 ± 1.73.0 ± 0.45.5 ± 1.111.3 ± 1.77.6 ± 0.4
  • Clinical data are presented for all patients involved in the study, either analyzed by microarrays, real-time RT-PCR, or both. Follow-up of the clinical data revealed in 2 (in boldface type) of the 30 patients with nodular glomerulosclerosis, no evidence for clinically overt diabetes but a light chain deposit disease in DN14 and unclassified nodular glomerulosclerosis with mesangial matrix expansion in DN15.