TABLE 3

ModelInspector analysis demonstrates a clear overrepresentation of the NF-κB module NFKB_IRFF_01 in 54 upregulated NF-κB–dependant target genes

ModulesInduced NF-κ B genes
Non-ind. NF-κ B genes
All human promoters
Number of matchesProbability (per 10,000 bp)Number of matchesProbability (per 10,000 bp)Number of matchesProbability (per 10,000 bp)
AP1F_NFKB_0120.2910.11530.02
AP1F_NFKB_0240.5810.11410.01
AP1F_NFKB_0300.0010.111450.04
AP1F_NFKB_0410.1510.11190.01
AP1F_NFKB_EBOX_0100.0010.1120.00
CEBP_NFKB_0100.0010.11340.01
CEBP_NFKB_0220.2910.111210.03
CEBP_NFKB_0410.1510.111110.03
CEBP_NFKB_0510.1500.001390.04
CEBP_NFKB_0650.7330.34>1,0000.43
CEBP_NFKB_NFAT_0200.0010.112040.06
CEBP_NFKB_STAT_0100.0010.1110.00
CREB_NFKB_0110.1510.111380.04
CREB_NFKB_0310.1500.001270.04
GATA_GATA_NFKB_NFKB_0110.1500.0010.00
IRFF_NFKB_0110.1500.001060.03
IRFF_NFKB_0300.0020.23700.02
NFKB_AP1F_0140.5860.68>1,0000.58
NFKB_AP1F_SP1F_0100.0020.23140.00
NFKB_CEBP_0110.1540.465960.17
NFKB_CREB_0160.8840.46>1,0000.58
NFKB_ETSF_0100.0010.11540.02
NFKB_IRFF_0150.7300.00620.02
NFKB_NFKB_0200.0010.1150.00
NFKB_NFKB_0330.4410.11400.01
NFKB_RBPF_0130.4460.683440.10
NFKB_SORY_01142.04111.257720.22
NFKB_SORY_02101.4650.573480.10
NFKB_STAT_0100.0020.23260.01
NFKB_STAT_0271.0291.02>1,0000.76
NFKB_STAT_NFKB_0120.2930.342650.08
SP1F_NFKB_0100.0010.11320.01
STAT_NFKB_0210.1500.00270.01
YY1F_NFKB_0110.1510.11500.01
  • Numbers of matches by ModelInspector (Genomatix) analyses of individual experimentally verified NF-κB containing promoter modules in proximal promoter sequences of 54 DN upregulated NF-κB target genes, 84 DN noninduced NF-κB target genes, and the whole human promoter library, including 50.145 proximal promoter sequences are depicted. Total length of analyzed proximal promoter sequences were 68.468 bp in upregulated NF-κB target genes, 87.856 bp in noninduced NF-κB target genes, and 35.125.826 bp in the whole human promoter library. Probabilities of matches with individual modules were shown as frequency of matches observed in 10.000 bp of analyzed proximal promoter sequences. Only the module NFKB_IRFF_01 (in boldface type) was significantly overrepresented in the proximal promoter sequences of induced NF-κB target genes compared with noninduced target genes (P < 0.05).