TABLE 1

Inhibitory effects of MgATP

Kir6.2 genotypeTetracycline (ng/ml)IC50 (μmol/l)hn
WT024.9 ± 6.11.2 ± 0.27
WT5017.2 ± 7.61.6 ± 0.37
R201H054.2 ± 7.3*1.3 ± 0.26
R201H502,021 ± 852*3.1 ± 2.24
  • Data are means ± SE, unless otherwise indicated.

  • *

    * P < 0.05 against wild-type (WT) equivalent. h, Hill coefficient; n, number of cells.