TABLE 2

Effect of PARP inhibition on the development of diabetic nephropathy in db/db mice

GroupAlbumin/ creatinine (μg/mg)Mesangial matrix scorePodocyte number/ glomerulus
db/m CTL39 ± 4.31.49 ± 0.2611.5 ± 1.5
db/m INO57 ± 5.51.4 ± 0.211 ± 0.7
db/db CTL1,036 ± 1803.6 ± 0.258.05 ± 1.4
db/db INO440 ± 71*2.3 ± 0.39*9.7 ± 0.4*
db/m CTL14 ± 11.2 ± 0.110.2 ± 0.4
db/db CTL721 ± 622.9 ± 0.37.5 ± 1
db/db PJ-34397 ± 37*1.4 ± 0.3*9.6 ± 1.4*
  • Data are means±SE. Albuminuria was measured by murine albumin-specific ELISA kit and creatinine with colorimetric reaction and are expressed as micrograms albumin per milligram creatinine. Mesangial matrix expansion was examined semiquantitatively on PAS-stained kidney sections. Podocyte number per glomerular cross section was counted on frozen sections by WT-1 and synaptopodin double labeling and expressed as mean podocyte number per glomerular cross section.

  • *

    * P < 0.05.