TABLE 3

Association of selected SNPs and haplotype with BMI for European and African-American populations

Populationnrs1044498 (Q)
rs1799774 (delT)
rs7754561 (G)
Haplotype (Q-delT-G)
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
U.S. and Poland Obese/lean1,918/9550.98 (0.84–1.15)0.840.85 (0.74–0.97)0.021.01 (0.87–1.12)0.830.96 (0.79–1.18)0.37
African American Obese/lean96/921.26 (0.76–2.07)0.370.87 (0.53–1.46)0.611.20 (0.72–2.02)0.48
Heritability
P
Heritability
P
Heritability
P
Heritability
P
African American Families8460.0090.72−0.0010.72−0.0020.79−0.000090.49
  • The association tests were done under multiplicative, dominant, and recessive models (multiplicative shown). SNP rs1799774 was also associated with BMI in the Caucasian population in a recessive model. Association testing for the African-American families was computed in PBAT (pedigree-based association testing software package), listing the heritability or effect estimate and the P value (residual of BMI adjusted for age and sex). To be consistent with the literature, ORs of individual SNPs are reported as minor vs. major allele.