TABLE 2

The frequency of HLA class II genotypes in 40 individuals with Down’s syndrome and diabetes, 222 individuals with Down’s syndrome, 120 sex- and age-matched individuals with type 1 diabetes, and 621 healthy control subjects

Healthy control subjectsDown’s syndromeDown’s syndrome and type 1 diabetesType 1 diabetes
n62122240120
Genotype
    DR4-DQ8/DR3-DQ217 (3)4 (2)10 (25)51 (43)
    DR4-DQ8/X85 (13)27 (12)7 (17)37 (31)
    DR3-DQ2/X167 (27)49 (22)11 (28)21 (17)
    X/X249 (40)94 (42)12 (30)10 (8)
    DR2-DQ6/ DR2-DQ6 or DR2-DQ6/X103 (17)48 (22)0 (0)1 (1)
  • Data are n (%). The genotypes HLA DRB1*04-DQB1*0302/HLA DRB1*03-DQB1*0201, HLA DRB1*04-DQB1*0302/X, and HLA DRB1*03-DQB1*0201/X are described as DR4-DQ8/DR3-DQ2, DR4-DQ8/X, and DR3-DQ2/X, respectively, where X is not HLA DRB1*02-DQB1*0602 (DR2-DQ6).