TABLE 2

Quantitative trait means (±SD) by TCF7L2 rs7903146 genotype at different times of the prospective study in control subjects

Quantitative traitA1 (n = 4,434)
A2 and A3 (n = 2,925)
C/CC/TT/TPC/CC/TT/TP
BMI (kg/m2)24.49 ± 3.6724.51 ± 3.7024.23 ± 3.520.3925.29 ± 3.8925.27 ± 3.7425.14 ± 3.760.84
ln(Fasting insulin) (pmol/l)3.68 ± 0.513.66 ± 0.513.61 ± 0.530.04*3.90 ± 0.573.89 ± 0.533.82 ± 0.550.09
ln(HOMA-B) (AU)4.41 ± 0.524.38 ± 0.524.35 ± 0.530.04*4.73 ± 0.544.71 ± 0.524.66 ± 0.600.18
ln(HOMA-IR) (AU)0.41 ± 0.550.39 ± 0.550.34 ± 0.560.070.61 ± 0.600.60 ± 0.560.52 ± 0.580.09
Fasting glucose (mmol/l)5.17 ± 0.475.18 ± 0.475.16 ± 0.490.615.03 ± 0.435.03 ± 0.455.01 ± 0.440.87
Cholesterol (mmol/l)5.72 ± 1.015.69 ± 0.995.72 ± 0.940.695.72 ± 0.905.73 ± 0.915.69 ± 0.930.77
HDL cholesterol (mmol/l)1.64 ± 0.421.64 ± 0.431.66 ± 0.440.741.54 ± 0.361.53 ± 0.361.55 ± 0.390.67
LDL cholesterol (mmol/l)3.56 ± 0.933.55 ± 0.903.57 ± 0.900.843.66 ± 0.793.67 ± 0.773.63 ± 0.770.73
Triglycerides (mmol/l)1.14 ± 0.761.12 ± 0.791.10 ± 0.660.591.14 ± 0.591.16 ± 0.611.10 ± 0.610.25
  • Data are means ± SD. A1: At baseline, all control participants. A2 and A3: Participants followed 9 years and remaining normoglycemic over the 9 years. P values are from linear regression models and are adjusted for BMI, age, and sex (BMI being adjusted for age and sex only).

  • *

    * No P values remained significant after Bonferroni correction. AU, arbitrary units.