TABLE 2

Main results of the association analysis of chromosome 3 SNPs with nephropathy status

Denmark
Finland
France
Combined*
Control subjectsCase subjectsControl subjectsCase subjectsControl subjectsCase subjects
n463489469387391300
SLC2A2_16459CT
    Allele frequencies0.876/0.1240.895/0.1050.847/0.1530.883/0.1170.861/0.1390.867/0.133
    OR (95% CI)0.76 (0.54–1.07)0.76 (0.56–1.03)0.88 (0.62–1.24)0.79 (0.66–0.96)
    P0.1120.0740.4630.016
KNG1_7965CT
    Allele frequencies0.521/0.4790.498/0.5020.525/0.4750.486/0.5140.542/0.4580.514/0.486
    OR (95% CI)1.11 (0.90–1.36)1.22 (0.99–1.50)1.18 (0.94–1.48)1.17 (1.03–1.32)
    P0.3510.0690.1500.016
ADIPOQ_Prom2GA
    Allele frequencies0.931/0.0690.909/0.0910.974/0.0260.974/0.0260.933/0.0670.903/0.097
    OR (95% CI)1.70 (1.13–2.55)0.91 (0.47–1.77)1.52 (0.97–2.38)1.46 (1.11–1.93)
    P0.0110.7840.0710.006
  • *

    * Pooled OR according to the Mantel-Haenszel method after having checked for the homogeneity across populations: SLC2A2, solute carrier family 2 (facilitated glucose transporter), member 2; KNG1, kininogen; and ADIPOQ, adiponectin. Assocation tests were performed while adjusting for sex, diabetes duration, HbA1c, and smoking, assuming either

  • additive or

  • dominant effects of the polymorphisms.