TABLE 3

Results of the TDT analyses in trios with and without diabetic nephropathy

TDT in trios with diabetic nephropathy
TDT in trios without diabetic nephropathy
n*TORn*TOR
SLC2A2_16459CT
    Denmark56.430.5131.05 (0.63–1.78)26.720.3850.63 (0.29–1.37)
    Finland24.010.6221.64 (0.72–3.77)29.010.4800.92 (0.45–1.92)
    France24.840.5961.48 (0.66–3.29)76.530.4190.72 (0.46–1.14)
    Test for homogeneity§P = 0.605P = 0.74
    Pooled1.26 (0.86–1.85)0.74 (0.52–1.04)
KNG_7965CT
    Denmark94.780.4960.98 (0.66–1.47)78.410.3960.66 (0.42–1.03)
    Finland58.000.3960.66 (0.39–1.11)60.000.5001.00 (0.60–1.66)
    France55.610.5611.28 (0.75–2.17)137.360.4720.89 (0.64–1.25)
    Test for homogeneity§P = 0.208P = 0.42
    Pooled0.95 (0.72–1.25)0.84 (0.66–1.07)
ADIPOQ_Prom2GA
    Denmark28.430.6862.18 (0.99–4.83)11.000.3500.54 (0.16–1.88)
    Finland6.000.3330.50 (0.09–2.73)3.000.3330.49 (0.04–5.45)
    France19.030.5631.29 (0.52–3.18)32.250.3330.49 (0.24–1.04)
    Test for homogeneity§P = 0.274P = 0.991
    Pooled1.52 (0.86–2.66)0.50 (0.27–0.92)
(P = 0.026)
  • *

    * Number of informative transmissions (in terms of heterozygous parent transmitting to an affected child).

  • Proportion of transmitted allele to diseased offspring (probands with or without diabetic nephropathy) in TDT analysis.

  • OR = T/(1 − T) is an estimate of the allelic OR under the assumption of additive effect (on a logistic scale).

  • §

    § Test for homogeneity of the combined OR across populations according to Mantel-Haenszel statistic.

  • Combined OR across populations according to Mantel-Haenszel statistic.

  • Associated P value.