TABLE 1

Homology between the human and studied insulin promoters

SpeciesRegion of human insulin promoter (bp)
−600 to −550−550 to −500−500 to −450−450 to −400−400 to −350−350 to −300−300 to + 1
Chimpanzee859092869410098
GorillaSNASNASNASNASNASNA98
OrangutanSNASNASNASNASNASNA97
African green monkeySNASNASNASNA729490
Rhesus macaque38423946759494
Owl monkeySNASNA4544699698
Pig46364660455065
Rat 135444843424966
Rat 229374345445564
Mouse 138493743465165
Mouse 239444942425068
Dog54355339597569
Cow48524957475767
Chicken24413432323037
Zebrafish36292229304441
  • Percent identity values were calculated for the principal insulin promoter (−300 to + 1) and 50-bp windows further upstream to −600 bp from the start of transcription. SNA, sequence not available.