TABLE 1

Effects of regulatory T-cells on β-cell dynamics following adoptive transfer of diabetogenic splenocytes

Transfer group	n	Rate of diabetes (%)	β-Cell area (cells/mm²)	β-Cell replication (%)	Active caspase-3⁺ β-cells (%)
Without Tregs	9	78	0.018 ± 0.005	2.95 ± 0.27	86.8 ± 6
With Tregs	5	20*	0.157 ± 0.05†	1.98 ± 0.27*	35.3 ± 1‡

Data are means ± SE unless otherwise indicated.
*
* P < 0.05,
†
† P < 0.02,
‡
‡ P = 0.002 (NOD/scid recipients of diabetogenic splenocytes and CD4⁺CD25⁺ vs. CD4⁺ CD25⁻ lymphocytes.