Effects of regulatory T-cells on β-cell dynamics following adoptive transfer of diabetogenic splenocytes
Transfer group | n | Rate of diabetes (%) | β-Cell area (cells/mm2) | β-Cell replication (%) | Active caspase-3+ β-cells (%) |
---|---|---|---|---|---|
Without Tregs | 9 | 78 | 0.018 ± 0.005 | 2.95 ± 0.27 | 86.8 ± 6 |
With Tregs | 5 | 20* | 0.157 ± 0.05† | 1.98 ± 0.27* | 35.3 ± 1‡ |
Data are means ± SE unless otherwise indicated.
* P < 0.05,
† P < 0.02,
‡ P = 0.002 (NOD/scid recipients of diabetogenic splenocytes and CD4+CD25+ vs. CD4+ CD25− lymphocytes.