TABLE 1

Effects of regulatory T-cells on β-cell dynamics following adoptive transfer of diabetogenic splenocytes

Transfer groupnRate of diabetes (%)β-Cell area (cells/mm2)β-Cell replication (%)Active caspase-3+ β-cells (%)
Without Tregs9780.018 ± 0.0052.95 ± 0.2786.8 ± 6
With Tregs520*0.157 ± 0.051.98 ± 0.27*35.3 ± 1
  • Data are means ± SE unless otherwise indicated.

  • *

    * P < 0.05,

  • P < 0.02,

  • P = 0.002 (NOD/scid recipients of diabetogenic splenocytes and CD4+CD25+ vs. CD4+ CD25 lymphocytes.