TABLE 2

Sciatic nerve sorbitol pathway intermediate concentrations (in nanomoles per milligram wet weight) in nondiabetic control and diabetic ob/ob mice with and without fidarestat treatment

GlucoseSorbitolFructose
Control2.20 ± 0.350.092 ± 0.0210.404 ± 0.162
Control + F2.23 ± 0.420.067 ± 0.0330.343 ± 0.157
ob/ob20.8 ± 2.0*0.196 ± 0.0353.34 ± 0.40*
ob/ob + F21.5 ± 3.4*0.099 ± 0.0310.903 ± 0.25§
  • Data are means ± SE; n = 8–10. Significantly different from nondiabetic controls (

  • *

    * P < 0.01 and

  • P < 0.05). Significantly different from untreated ob/ob mice (

  • P < 0.05 and

  • §

    § P < 0.01). F, fidarestat.