TABLE 1

Islet allograft survival without immunosuppression

GroupMiceSitenSurvival (individual days)Mean survival time (means ± SE)
IWild typeKidney capsule413, 15, 18, 2417.5 ± 2.4
IIWild typePortal vein97, 7, 9, 9, 9, 9, 11, 11, 119.2 ± 0.5
IIICD1d−/−Kidney capsule312, 16, 1715.0 ± 1.5
IVCD1d−/−Portal vein713, 16, 16, 26, 30, 31, 3423.7 ± 3.2*
VVα14NKT−/−Kidney capsule511, 15, 15, 16, 1815.0 ± 1.1
VIVα14NKT−/−Portal vein615, 17, 19, 20, 26, 5224.8 ± 5.6*
  • BALC/c islets were transplanted beneath the kidney capsule or into the liver via the portal vein of STZ-induced diabetic C57BL/6 wild-type, CD1d−/−, or Vα14 NKT cell−/− mice.

  • *

    * The difference is statistically significant (P < 0.01, log rank test) compared with the corresponding control (II).