TABLE 2

Islet allograft survival in mice treated with rapamycin

GroupMiceSiteRapamycin (mg/kg)nSurvival (days)% Survival at 90 days
IWild typePortal vein97, 7, 9, 9, 9, 9, 11, 11, 110
IIWild typePortal vein0.298, 9, 10, 13, 15, 18, 22, 25, 260
IIIWild typePortal vein1.0814, 27, 33, 36, 39, 45, 46, >9012.5
IVWild typePortal vein3.0739, 54, >90 (×5)71.4
VCD1d−/−Portal vein1.01154, >90 (×10)91.0*
VIVα14NKT−/−Portal vein1.0541, 54, >90 (×3)60.0
  • BALB/c islets were grafted into the liver of STZ-induced diabetic C57L/6 mice treated with rapamycin, which was administered intraperitoneally once a day for 6 days after transplantation.

  • *

    * P < 0.01 vs. the corresponding control (III) by Fisher’s exact probability test.