TABLE 2

High-resolution mapping of the Idd4.2 locus

MarkerPositionNOR-R1NOR-R3NOD-R1
D11Mit36471958448NNNNBB
D11Mit21972044629NNNNBB
D11Jyh52272136258NNNNBB
D11Jyh54872236138NNNNBB
D11Jyh58272568517NNNNBB
D11Jyh59872706982NNNNBB
D11Gul472723423NNNNBB
D11Gul572728763NNNNNN
D11Jyh60872760171NNNNNN
D11Jyh61172807577NNNNNN
D11Jyh61672845534NNNNNN} 0.41 Mb} 0.92 Mb
D11Jyh61872848262NNNNNN
D11Jyh62972971220NNNNNN
D11Gul1472986906NNNNNN
D11Gul3373133966NNNNNN
D11Gul8073645126NNBBNN
D11Gul9673894486BBBBNN
D11Jyh30673988252BBBBNN
D11Jyh16475329443BBBBNN
D11Jyh13475554436BBBBNN
D11Jyh10775860300BBBBNN
D11Jyh10475961098BBBBNN
D11Jyh9676227476BBBBNN
D11Mit32276304982BBBBNN
D11Bhm14977408880BBBBNN
D11Mit3381507909NNNNNN
  • For the fine mapping of the Idd4.2 locus, we genotyped informative congenic strains (NOR-R1, NOR-R3, and NOD-R1) with microsatellite markers polymorphic between NOD and NOR strains. All three strains are CY-T1D susceptible compared with the corresponding parental strain (Figs. 1 and 2). The genotype at each marker is shown as either NN (NOD derived) or BB (NOR derived). Position of the each marker is according to the Ensembl database (http://www.ensembl.org/mouse). Sizes of the minimal and the most conservative estimates of the Idd4.2 locus are also indicated. Genotypes of the mice within minimal interval region are shown in bold font. The genotype of the NOR-R4 strain was not included in this table because it was identical to the NOR-R3, most likely reflecting a common genetic ancestor for these two strains.