TABLE 2

Genotype counts for the KLF11 Q62R polymorphism in the various subsamples

Family basedTransmitted
Untransmitted
MAFOR (95% CI)P value
Trios27
36
0.090.75 (0.46–1.23)0.26
Discordant sibsExcess in affected
Excess in unaffected
23250.090.92 (0.52–1.62)0.77
Case/controlG/G (R/R)A/G (Q/R)A/A (Q/Q)
Scandinavia
    Case subjects7743880.09
    Control subjects8663940.091.08 (0.79–1.48)0.64
Sweden
    Case subjects7884090.10
    Control subjects3904100.101.07 (0.80–1.43)0.66
Canada
    Case subjects223860.12
    Control subjects422830.140.87 (0.50–1.51)0.62
GCI U.S.
    Case subjects162539380.12
    Control subjects152639200.120.96 (0.81–1.14)0.65
GCI Poland
    Case subjects181758070.11
    Control subjects111937930.110.98 (0.80–1.19)0.81
Overall0.97 (0.88–1.08)0.63
  • The transmission disequilibrium test and the discordant allele test were performed in the Scandinavian trios and the discordant sibpairs, respectively. ORs were calculated for the minor allele (G, coding for arginine) versus the major allele (A, coding for glutamine) and pooled by Mantel-Haenszel analysis. MAF, minor allele frequency.